Imagine Global Strategic Alliance Scholarship
The Florey Institute and Imagine: Imaging Life are long term strategic initiatives at the University of Sheffield (2022 Futures) that provide a platform for ambitious research growth in areas that the University of Sheffield is recognised for internationally. The Florey Institute aims to create a world-leading focus on antimicrobial resistance and host-pathogen interactions, from fundamental science to translation. Imagine: Imaging Life aims to combine and harness cutting-edge imaging technologies in super-resolution microscopy, electron microscopy and atomic force microscopy to address key biological questions. This scholarship, as part of the Global Strategic Alliance programme, will position the student in a thriving research environment that may provide international opportunities for training and career development.
Project title: How do immune cells eat microbes?
Project description: Macrophages are immune cells that directly kill infectious microbes. Ingestion (phagocytosis) of microbes is needed for the clearance of infection. Despite the importance of phagocytosis there are many fundamental aspects that are not understood.
This project is interdisciplinary and would suit an applicant from either a biological or physical sciences background.
In this project we will focus on how the size, shape and stiffness of microbes affects the ability of macrophages to ingest them. We will use cutting edge microscopy (super resolution STORM and SIM, electron, and light sheet microscopy) combined with biophysical modeling to define the important parameters governing the mechanics of phagocytosis. The recent revolution in optical microscopy allows us to beat the diffraction limit, enabling us to image individual fluorescent molecules in cells. Where necessary in the project we will development bespoke microscopes. We will use medically relevant microbes of different shapes, sizes and surface properties (e.g. Staphylococcus aureus and Mycobacteria tuberculosis). These measurements will inform our theoretical models predicting success of phagocytosis for different microbes.
If you would like to know more about the project or application please contact Dr Simon Johnston (email@example.com) or Dr Rhoda Hawkins (firstname.lastname@example.org).
You should be available for interview on 5th April 2017.
• Full tuition fees (Overseas, EU or Home).
• An annual, tax-free maintenance stipend at the standard RCUK rate.
These scholarships fund up to 3.5 years full-time study, subject to satisfactory progress.
• This project is interdisciplinary and would suit an applicant from either a biological or physical sciences background. The successful candidate will have a good (1st/high 2.1 equivalent) degree in a relevant science subject with research experience (e.g. Undergraduate/Masters research project).
• Anticipated start date October 2017
• Awards are open to International, EU and UK applicants.
How to apply
Scholarships are awarded on a competitive basis - applications are assessed on the basis of academic success and qualifications, experience, research background and a clear and well-articulated reason for being considered. For information on applying, please see https://www.sheffield.ac.uk/postgraduate/research/apply/applying